Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.[5][6]

MAP3K13
Identifiers
AliasesMAP3K13, LZK, MEKK13, MLK, mitogen-activated protein kinase kinase kinase 13
External IDsOMIM: 604915; MGI: 2444243; HomoloGene: 37958; GeneCards: MAP3K13; OMA:MAP3K13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242314
NM_001242317
NM_004721

NM_172821

RefSeq (protein)

NP_001229243
NP_001229246
NP_004712

NP_766409

Location (UCSC)Chr 3: 185.28 – 185.49 MbChr 16: 21.61 – 21.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.[6]

Interactions

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MAP3K13 has been shown to interact with PRDX3.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073803Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033618Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.
  6. ^ a b "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".
  7. ^ Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.

Further reading

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