This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Insomnia
editGABAA receptor potentiators
edit- EVT-201 – GABAA receptor positive allosteric modulator[1]
- Lorediplon (GF-015535-00) – GABAA receptor positive allosteric modulator [2]
- Zuranolone (SAGE-217) – GABAA receptor positive allosteric modulator [3]
Orexin receptor antagonists
edit- Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX2 receptor antagonist [4]
- Vornorexant (ORN-0829, TS-142) – dual OX1 and OX2 receptor antagonist [5]
Melatonin receptor agonists
edit- Piromelatine (Neu-P11) – melatonin receptor agonist and 5-HT1A and 5-HT1D receptor agonist [6]
Nociceptin receptor agonists
edit- Sunobinop (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist [7][8]
Hypersomnia/narcolepsy
editOrexin receptor agonists
edit- ALKS-2680 – selective OX2 receptor agonist[1]
- Danavorexton (TAK-925) – selective OX2 receptor agonist via IV infusion[2][9]
- E-2086 – selective OX2 receptor agonist[3]
- Firazorexton (TAK-994) – OX2 receptor agonist pill (orally available)[10][2]
- Suntinorexton (TAK-861) – selective OX2 receptor agonist (orally available) [11][4]
Monoaminergics
edit- Flecainide/modafinil (THN-102) – modafinil (dopamine reuptake inhibitor) and flecainide (antiarrhythmic) combination [12]
- Mazindol controlled release (NLS-1001, NLS-1) – norepinephrine-predominant serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)[13]
- Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) [14]
GHB receptor agonists
editH3 receptor inverse agonists
edit- Samelisant (SUVN-G3031) – H3 receptor antagonist [15]
GABAA receptor inhibitors
edit- Pentylenetetrazole (BTD-001) – GABAA receptor negative allosteric modulator [16]
See also
editReferences
edit- ^ "ALKS 2680". AdisInsight. 7 June 2024. Retrieved 31 July 2024.
- ^ a b "Takeda". www.ox2rsparkleprogram.com. Retrieved 2019-11-15.
- ^ "E-2086". AdisInsight. 15 July 2024. Retrieved 31 July 2024.
- ^ Konofal, Eric (2024). "From past to future: 50 years of pharmacological interventions to treat narcolepsy". Pharmacology Biochemistry and Behavior. 241: 173804. doi:10.1016/j.pbb.2024.173804.
