These are the singles that reached number one on the Top 100 Singles chart in 1995 as published by Cash Box magazine.
| † | Indicates best-performing single of 1995 |
| Issue date | Song | Artist |
|---|---|---|
| January 7 | "On Bended Knee" | Boyz II Men |
| January 14 | ||
| January 21 | ||
| January 28 | ||
| February 4 | ||
| February 11 | ||
| February 18 | "Take a Bow" | Madonna |
| February 25 | ||
| March 4 | ||
| March 11 | ||
| March 18 | ||
| March 25 | ||
| April 1 | ||
| April 8 | ||
| April 15 | "I Know" | Dionne Farris |
| April 22 | ||
| April 29 | ||
| May 6 | ||
| May 13 | ||
| May 20 | ||
| May 27 | "Water Runs Dry" | Boyz II Men |
| June 3 | ||
| June 10 | ||
| June 17 | ||
| June 24 | ||
| July 1 | "Have You Ever Really Loved a Woman?" | Bryan Adams |
| July 8 | "Waterfalls" | TLC |
| July 15 | ||
| July 22 | ||
| July 29 | ||
| August 5 | ||
| August 12 | ||
| August 19 | ||
| August 26 | "Kiss from a Rose" † | Seal |
| September 2 | "You Are Not Alone" | Michael Jackson |
| September 9 | ||
| September 16 | "Gangsta's Paradise" | Coolio featuring L.V. |
| September 23 | ||
| September 30 | ||
| October 7 | "Fantasy" | Mariah Carey |
| October 14 | ||
| October 21 | ||
| October 28 | ||
| November 4 | ||
| November 11 | ||
| November 18 | ||
| November 25 | ||
| December 2 | ||
| December 9 | "One Sweet Day" | Mariah Carey & Boyz II Men |
| December 16 | ||
| December 23 | ||
| December 30 |