LY-456220 is a potent and selective serotonin 5-HT1D receptor antagonist which has been used in research to study the function of presynaptic 5-HT1D autoreceptors. LY-456220 lacks significant affinity for the 5-HT1B, α1 adrenergic, and dopamine D2 receptors.[1][2]
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Formula | C25H26FN3O2 |
Molar mass | 419.500 g·mol−1 |
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References
edit- ^ Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, et al. (June 2004). "The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig". European Journal of Pharmacology. 493 (1–3): 85–93. doi:10.1016/j.ejphar.2004.04.029. PMID 15189767.
- ^ Timms GH, Boot JR, Broadmore RJ, Carney SL, Cooper J, Findlay JD, et al. (May 2004). "SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis". Bioorganic & Medicinal Chemistry Letters. 14 (10): 2469–72. doi:10.1016/j.bmcl.2004.03.003. PMID 15109634.