U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.[5][6][7]

LSM4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM4, GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607284; MGI: 1354692; HomoloGene: 134555; GeneCards: LSM4; OMA:LSM4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012321
NM_001252129

NM_015816
NM_001359042

RefSeq (protein)

NP_001239058
NP_036453

NP_056631
NP_001345971

Location (UCSC)Chr 19: 18.31 – 18.32 MbChr 8: 71.13 – 71.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130520Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031848Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  6. ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  7. ^ a b "Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading

edit