Lipoic acid synthetase is a protein that in humans is encoded by the LIAS gene. [5]

LIAS
Identifiers
AliasesLIAS, LAS, LIP1, LS, PDHLD, HUSSY-01, HGCLAS, lipoic acid synthetase
External IDsOMIM: 607031; MGI: 1934604; HomoloGene: 4997; GeneCards: LIAS; OMA:LIAS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024471
NM_001310612

RefSeq (protein)

NP_001297541
NP_077791

Location (UCSC)Chr 4: 39.46 – 39.49 MbChr 5: 65.55 – 65.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121897Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029199Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lipoic acid synthetase". Retrieved 2018-02-17.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.