Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[5][6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

LGR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDsOMIM: 606666; MGI: 1891468; HomoloGene: 10226; GeneCards: LGR4; OMA:LGR4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018490
NM_001346432

NM_172671

RefSeq (protein)

NP_001333361
NP_060960

NP_766259

Location (UCSC)Chr 11: 27.37 – 27.47 MbChr 2: 109.75 – 109.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205213Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050199Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.
  6. ^ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Further reading

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