Placental protein 13 (PP13) is a protein that in humans is encoded by the LGALS13 gene.[3][4]

LGALS13
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesLGALS13, GAL13, PLAC8, PP13, galectin 13
External IDsOMIM: 608717; HomoloGene: 49329; GeneCards: LGALS13; OMA:LGALS13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013268

n/a

RefSeq (protein)

NP_037400

n/a

Location (UCSC)Chr 19: 39.6 – 39.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Structure and function

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Function

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It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galactoside. This is because the ligand binding site is lack of key residue for binding beta-galactoside. [5]It is a galectin-like protein. The ligand of this protein is still unknown.

Clinical significance

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PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105198Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID 6856484.
  4. ^ Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID 10527825.
  5. ^ Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC 5772480. PMID 29343868.
  6. ^ Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi:10.1093/humupd/dmt003. PMID 23420029.
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  • Overview of all the structural information available in the PDB for UniProt: Q9UHV8 (Human Galactoside-binding soluble lectin 13) at the PDBe-KB.