L-687,384

L-687,384
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine];
CAS Number	95417-67-7 ;
PubChem CID	125328;
ChemSpider	111534 ;
UNII	NVE9K68QA3;
ChEMBL	ChEMBL303336;
CompTox Dashboard (EPA)	DTXSID30241828 ;
Chemical and physical data
Formula	C21H25N
Molar mass	291.438 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4;
	InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 ; Key:MLDCBJPLHBPJET-UHFFFAOYSA-N ;
	(what is this?) (verify)

L-687,384 is a sigma receptor agonist, selective for the σ₁ subtype,^[1] as well as an NMDA antagonist.^[2]

References

^ Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology. 129 (3): 215–24. doi:10.1007/s002130050183. PMID 9084059. S2CID 24537111.
^ McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters. 174 (2): 181–4. doi:10.1016/0304-3940(94)90016-7. PMID 7526288. S2CID 10876486.
^ Quaglia W, Giannella M, Piergentili A, Pigini M, Brasili L, Di Toro R, Rossetti L, Spampinato S, Melchiorre C. 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. J Med Chem. 1998 May 7;41(10):1557-60. doi: 10.1021/jm970740r. PMID 9572880.

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Clinical data

ATC code	none
Identifiers
IUPAC name 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
CAS Number	95417-67-7^Y
PubChem CID	125328
ChemSpider	111534^N
UNII	NVE9K68QA3
ChEMBL	ChEMBL303336
CompTox Dashboard (EPA)	DTXSID30241828
Chemical and physical data
Formula	C₂₁H₂₅N
Molar mass	291.438 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4
InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2^N Key:MLDCBJPLHBPJET-UHFFFAOYSA-N^N
^NY (what is this?) (verify)