Juan Cruz may refer to:
- Juan Cruz (baseball) (born 1978), Dominican pitcher
- Juan Cruz (director) (born 1966), Spanish screenwriter and film director
- Juan Aubín Cruz Manzano (born 1948), Puerto Rican politician and mayor of Manatí since 1977
- Juan R. Cruz (born 1946), Puerto Rican aerospace engineer at the National Aeronautics and Space Administration
- Juan Lazo Cruz (born 1977), Salvadoran football midfielder
- Juan Cruz (footballer, born 1992), Spanish footballer
- Juan Cruz Bolado (born 1997), Argentine footballer
- Juan Cruz (footballer, born 2000), Spanish footballer
- Juan Cruz Real (born 1976), Argentine footballer and manager