John S. Macdonald may refer to:
- John Sandfield Macdonald, first Premier of Ontario
- Harry Macdonough (John Scantlebury Macdonald), Canadian singer and recording executive of the early 20th century
- John S. MacDonald, Canadian engineer and businessman
- John Smyth Macdonald (1867–1941), British physiologist
See also
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This disambiguation page lists articles about people with the same name.
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