John Holles may refer to:
- John Holles, 1st Duke of Newcastle-upon-Tyne (9 January 1662 – 15 July 1711)
- John Holles, 1st Earl of Clare (May 1564 – 4 October 1637)
- John Holles, 2nd Earl of Clare
This disambiguation page lists articles about people with the same name.
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