Jessel or Jessell is a surname. Notable people with the surname include:
- Sir Charles Jessel, (1860–1928), baronet, British barrister, magistrate and businessman
- Jesselton, now Kota Kinabalu, Sabah, Malaysia
- David Jessel, British journalist
- George Jessel:
- George Jessel (actor) (1898–1981), American vaudevillian
- George Jessel (jurist) (1824–1883), British jurist
- Herbert Jessel, 1st Baron Jessel (1866–1950), British soldier and politician
- Leon Jessel, German composer
- Patricia Jessel, actress
- Stephen Jessel, British correspondent
- Ray Jessel (1929—2015), American-Welsh composer
- Thomas Jessell, scientist
- Toby Jessel, British politician
- Kenneth A. Jessell, educator and 6th President of Florida International University
Fictional people
edit- Miss Jessel, a character in Henry James's The Turn of the Screw and its adaptations