Isaac Mercer may refer to:
- Isaac Mercer (1910–2002), Newfoundland lawyer and politician
- Isaac Mercer (Bay de Verde), who represented Bay de Verde in the Newfoundland assembly from 1902 to 1904 in 1900 Newfoundland general election
- Isaac Mercer (died 1860), whose murder led to a ban on the practice of mummering in Newfoundland
This disambiguation page lists articles about people with the same name.
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