Isaac Collins may refer to:
- Isaac Collins (printer) (1746–1817), colonial printer, publisher, bookseller and merchant
- Isaac Clinton Collins (1824–1879), American politician
- Isaac J. Collins (1874–1975), American businessman, founder of the Anchor Hocking
- Isaac Collins (American football), American gridiron football coach and player
This disambiguation page lists articles about people with the same name.
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