Isaac Brown may refer to:
- Isaac H. Brown (1812–1880), American sexton
- Issac Ryan Brown (born 2005), American actor
- Isaac Van Arsdale Brown (1784–1861), American educator and Presbyterian clergyman who founded the Lawrenceville School in New Jersey
- Isaac Brown (basketball) (born 1969), American basketball coach
- Isaac Brown (naval officer) (1817–1889), American naval officer in the US and Confederate navies
- Isaac Brown (American football), American football player
- Ike Brown (1942–2001), American baseball player
See also
edit- Isaac Brown House, a single-family home in Kalamazoo, Michigan
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