Ioannis Papaioannou (born 1976) is a Greek chess grandmaster.
Ioannis Papaioannou may also refer to:
- Giannis Papaioannou (1913–1972), Greek rembetiko composer
- Ioannis Papaioannou (actor) (1869–1931), Greek comic actor of musical theater and Greek troupe leader of operetta
- Yiannis Papaioannou (1910–1989), Greek composer and teacher of the Modern Era