Intraneural perineurioma

An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.

Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis.[1]

Due to the involvement of one or more nerve fascicles, intraneural perineuriomas are distinguished by a localized, solitary expansion of peripheral nerves. These tumors develop slowly or stay stable over time.[2]

References

edit
  1. ^ Boyanton BL Jr; Jones JK; Shenaq SM; Hicks MJ; Bhattacharjee MB (2007). "Intraneural perineurioma: a systematic review with illustrative cases". Archives of Pathology & Laboratory Medicine. 131 (9): 1382–92. doi:10.5858/2007-131-1382-IPASRW. PMID 17824794.
  2. ^ Mauermann, M. L.; Amrami, K. K.; Kuntz, N. L.; Spinner, R. J.; Dyck, P. J.; Bosch, E. P.; Engelstad, J.; Felmlee, J. P.; Dyck, P. J. (2009). "Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth". Brain. 132 (Pt 8): 2265–2276. doi:10.1093/brain/awp169. PMC 2724918. PMID 19567701.

Further reading

edit