Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.[5][6]

ITGA11
Identifiers
AliasesITGA11, HsT18964, integrin subunit alpha 11
External IDsOMIM: 604042, 604789; MGI: 2442114; HomoloGene: 8151; GeneCards: ITGA11; OMA:ITGA11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004439
NM_012211

NM_176922

RefSeq (protein)

NP_001004439

n/a

Location (UCSC)Chr 15: 68.3 – 68.43 MbChr 9: 62.59 – 62.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.[6]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.[7] Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal fibrosis, and lung fibrosis tissues.[8] ITGA11 has also been found to be upregulated in the tumor stroma of pancreatic ductal adenocarcinoma. [9] Knocking down of ITGA11 in human pancreatic stellate cells led to the inhibition of their differentiation into myofibroblasts and paracrine effect on tumor cells. [9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137809Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032243Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, et al. (September 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics. 60 (2): 179–187. doi:10.1006/geno.1999.5909. PMID 10486209.
  6. ^ a b "Entrez Gene: ITGA11 integrin, alpha 11".
  7. ^ Byström B, Carracedo S, Behndig A, Gullberg D, Pedrosa-Domellöf F (November 2009). "Alpha11 integrin in the human cornea: importance in development and disease". Investigative Ophthalmology & Visual Science. 50 (11): 5044–5053. doi:10.1167/iovs.08-3261. PMID 19516006.
  8. ^ Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, et al. (November 2017). "Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases". Experimental & Molecular Medicine. 49 (11): e396. doi:10.1038/emm.2017.213. PMC 5704196. PMID 29147013.
  9. ^ a b Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J (May 2019). "Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer". FASEB Journal. 33 (5): 6609–6621. doi:10.1096/fj.201802336R. PMID 30808244. S2CID 73482848.

Further reading

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