Inositol monophosphatase 2

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[4][5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

IMPA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIMPA2, inositol monophosphatase 2
External IDsOMIM: 605922; MGI: 2149728; HomoloGene: 22799; GeneCards: IMPA2; OMA:IMPA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014214

NM_053261

RefSeq (protein)

NP_055029

NP_444491

Location (UCSC)Chr 18: 11.98 – 12.03 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141401Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. S2CID 24336959.
  5. ^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
  6. ^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: O14732 (Human Inositol monophosphatase 2) at the PDBe-KB.