Independent School League or ISL may refer to:
- Independent School League (Illinois), a group of nine Chicago-area preparatory schools
- Independent School League (New England), a group of 16 New England preparatory schools
- Independent School League (Washington, D.C. area), a group of 17 Washington, D.C. preparatory schools
- Interscholastic League of Honolulu, a group of Hawaiian private schools
See also
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