Ibuzatrelvir (development code PF-07817883) is an experimental antiviral drug being developed by Pfizer for the treatment of COVID-19.[1] It is a second-generation improvement over nirmatrelvir which has a similar chemical structure.[2] One of the disadvantages of nirmatrelvir is that it has low metabolic stability and must be given in combination with ritonavir (as Paxlovid) to limit its metabolic degradation in the body.[3] Ibuzatrelvir incorporates modifications to the chemical structure of nirmatrelvir that give it enhanced oral bioavailability, so it does not require coadministration with ritonavir.[3]
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Other names | PF-07817883 |
Routes of administration | Oral |
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Formula | C21H30F3N5O5 |
Molar mass | 489.496 g·mol−1 |
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References
edit- ^ Allerton, Charlotte M. N.; et al. (2024). "A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.3c02469. PMID 38687966.
- ^ Chen, Pu; Van Oers, Tayla J.; Arutyunova, Elena; Fischer, Conrad; Wang, Chaoxiang; Lamer, Tess; Van Belkum, Marco J.; Young, Howard S.; Vederas, John C.; Lemieux, M. Joanne (2024). "A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV". Jacs Au. doi:10.1021/jacsau.4c00508.
- ^ a b Brewitz, Lennart; Schofield, Christopher J. (2024). "Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment". Journal of Medicinal Chemistry. 67 (14): 11656–11661. doi:10.1021/acs.jmedchem.4c01342. PMC 11284777. PMID 38967233.