Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.[4]

INTS12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINTS12, INT12, PHF22, SBBI22, integrator complex subunit 12
External IDsOMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142471
NM_020395

NM_027927

RefSeq (protein)

NP_001135943
NP_065128
NP_001135943.1
NP_065128.2

NP_082203

Location (UCSC)n/aChr 3: 132.8 – 132.82 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2)[4][5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028016Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: integrator complex subunit 12". Retrieved 2011-08-30.
  5. ^ Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.

Further reading

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