INPP1

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

INPP1
Identifiers
Aliases	INPP1, inositol polyphosphate-1-phosphatase
External IDs	OMIM: 147263; MGI: 104848; HomoloGene: 1655; GeneCards: INPP1; OMA:INPP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.2 Start 190,343,570 bp End 190,371,665 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C1.1|1 26.99 cM Start 52,824,586 bp End 52,856,847 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm corpus callosum middle frontal gyrus mucosa of pharynx cervix epithelium inferior ganglion of vagus nerve left testis epithelium of nasopharynx right testis duodenum Top expressed in granulocyte neural layer of retina cerebellar cortex thymus dentate gyrus of hippocampal formation granule cell spermatid seminal vesicula superior frontal gyrus lobe of cerebellum seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol-1,4-bisphosphate 1-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity hydrolase activity metal ion binding protein binding Cellular component cytosol Biological process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process signal transduction dephosphorylation inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3628 16329 Ensembl ENSG00000151689 ENSMUSG00000026102 UniProt P49441 P49442 RefSeq (mRNA) NM_001128928 NM_002194 NM_008384 RefSeq (protein) NP_001122400 NP_002185 NP_032410 Location (UCSC) Chr 2: 190.34 – 190.37 Mb Chr 1: 52.82 – 52.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Majerus PW, Ross TS, Cunningham TW, et al. (1990). "Recent insights in phosphatidylinositol signaling". Cell. 63 (3): 459–65. doi:10.1016/0092-8674(90)90442-H. PMID 2225061. S2CID 29563486.
• Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
• Steen VM, Løvlie R, Osher Y, et al. (1998). "The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness". Pharmacogenetics. 8 (3): 259–68. doi:10.1097/00008571-199806000-00008. PMID 9682271.
• Løvlie R, Gulbrandsen AK, Molven A, Steen VM (2000). "Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)". Pharmacogenetics. 9 (4): 517–28. PMID 10780272.
• Patel S, Yenush L, Rodríguez PL, et al. (2002). "Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy". J. Mol. Biol. 315 (4): 677–85. doi:10.1006/jmbi.2001.5271. PMID 11812139.
• Piccardi MP, Ardau R, Chillotti C, et al. (2002). "Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes". Psychiatr. Genet. 12 (1): 23–7. doi:10.1097/00041444-200203000-00003. PMID 11901356. S2CID 24222446.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.