IMP3

U3 small nucleolar ribonucleoprotein protein IMP3 is a protein that in humans is encoded by the IMP3 gene.

IMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQJ
Identifiers
Aliases	IMP3, BRMS2, C15orf12, MRPS4, U3 small nucleolar ribonucleoprotein, IMP U3 small nucleolar ribonucleoprotein 3
External IDs	OMIM: 612980 MGI: 1916119 HomoloGene: 6120 GeneCards: IMP3
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.2 Start 75,639,085 bp End 75,648,706 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 56,844,759 bp End 56,845,682 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen right lobe of liver right adrenal gland left adrenal gland spleen gastrocnemius muscle nipple cerebellar vermis body of stomach nucleus accumbens Top expressed in medial ganglionic eminence condyle fossa lip endocardial cushion parotid gland renal corpuscle islet of Langerhans thymus calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome rRNA binding protein binding snoRNA binding RNA binding Cellular component small ribosomal subunit small-subunit processome Mpp10 complex nucleolus intracellular anatomical structure nucleus nucleoplasm preribosome Biological process positive regulation of translational fidelity ribosome biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55272 102462 Ensembl ENSG00000177971 ENSMUSG00000032288 UniProt Q9NV31 Q921Y2 RefSeq (mRNA) NM_018285 NM_133976 RefSeq (protein) NP_060755 NP_598737 Location (UCSC) Chr 15: 75.64 – 75.65 Mb Chr 9: 56.84 – 56.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Cross SH, Charlton JA, Nan X, Bird AP (March 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Li C, Rock KL, Woda BA, Jiang Z, Fraire AE, Dresser K (February 2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression". Modern Pathology. 20 (2): 242–7. doi:10.1038/modpathol.3800735. PMID 17192788.

Sources

• http://www.imp3.org/