IFNA16

Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene.

IFNA16
Identifiers
Aliases	IFNA16, IFN-alphaO, IFN-alpha-16, interferon, alpha 16, interferon alpha 16
External IDs	OMIM: 147580; MGI: 2667155; HomoloGene: 105364; GeneCards: IFNA16; OMA:IFNA16 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 21,216,373 bp End 21,217,311 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 42.02 cM Start 88,561,878 bp End 88,562,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cell monocyte Top expressed in embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3449 230396 Ensembl ENSG00000147885 ENSMUSG00000063376 UniProt P05015 Q80SU4 RefSeq (mRNA) NM_002173 NM_177347 RefSeq (protein) NP_002164 NP_796321 Location (UCSC) Chr 9: 21.22 – 21.22 Mb Chr 4: 88.56 – 88.56 Mb PubMed search
Wikidata
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Further reading

• Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology. 193 (1): 303–12. doi:10.1006/viro.1993.1126. PMID 8438572.
• Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID 7913356.
• Dianzani F, Castilletti C, Gentile M, Gelderblom HR, Frezza F, Capobianchi MR (1998). "Effects of IFN alpha on late stages of HIV-1 replication cycle". Biochimie. 80 (8–9): 745–54. doi:10.1016/S0300-9084(99)80028-5. PMID 9865497.
• Zagury JF, Chams V, Lachgar A, Achour A, Bizzini B, Burny A, Zagury D, Feldman M (1995). "Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis?". Cell Death Differ. 2 (1): 23–32. PMID 17180012.
• Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4. doi:10.1074/jbc.C100583200. PMID 11694501.
• Cicala C, Arthos J, Selig SM, Dennis Jr G, Hosack DA, Van Ryk D, Spangler ML, Steenbeke TD, Khazanie P (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi:10.1073/pnas.142287999. PMC 123149. PMID 12089333.
• Schmidt B, Ashlock BM, Foster H, Fujimura SH, Levy JA (2005). "HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration". Virology. 343 (2): 256–66. doi:10.1016/j.virol.2005.09.059. PMID 16278001.
• Kinzl P, Otani T, Benz R, Minowada J (1997). "Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro". Microbiol. Immunol. 41 (9): 709–16. doi:10.1111/j.1348-0421.1997.tb01915.x. PMID 9343822. S2CID 85304106.
• Francis ML, Meltzer MS (1993). "Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication". J. Immunol. 151 (4): 2208–16. doi:10.4049/jimmunol.151.4.2208. PMID 8345204.
• Peng G, Lei KJ, Jin W, Greenwell-Wild T, Wahl SM (2006). "Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity". J. Exp. Med. 203 (1): 41–6. doi:10.1084/jem.20051512. PMC 2118075. PMID 16418394.
• Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
• Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA (2010). "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer. 9 (4): 625–33. doi:10.1007/s10689-010-9356-3. PMC 3233727. PMID 20574843.
• Popik W, Hesselgesser JE, Pitha PM (1998). "Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway". J. Virol. 72 (8): 6406–13. doi:10.1128/JVI.72.8.6406-6413.1998. PMC 109793. PMID 9658081.
• Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation". J. Leukoc. Biol. 62 (1): 49–53. doi:10.1002/jlb.62.1.49. PMID 9225992. S2CID 31546644.
• Del Cornò M, Gauzzi MC, Penna G, Belardelli F, Adorini L, Gessani S (2005). "Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells". J. Virol. 79 (19): 12597–601. doi:10.1128/JVI.79.19.12597-12601.2005. PMC 1211530. PMID 16160188.
• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi:10.1016/S0021-9258(18)42719-6. PMID 1371992.
• Taoufik Y, Lantz O, Wallon C, Charles A, Dussaix E, Delfraissy JF (1997). "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect". Blood. 89 (8): 2842–8. doi:10.1182/blood.V89.8.2842. PMID 9108403.
• Conti L, Fantuzzi L, Del Cornò M, Belardelli F, Gessani S (2004). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
• Schols D, De Clercq E (1996). "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production". J. Virol. 70 (8): 4953–60. doi:10.1128/JVI.70.8.4953-4960.1996. PMC 190447. PMID 8764000.
• Ankel H, Capobianchi MR, Frezza F, Castilletti C, Dianzani F (1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi:10.1006/viro.1996.0357. PMID 8661419.