Hydroxymandelonitrile glucosyltransferase

In enzymology, a hydroxymandelonitrile glucosyltransferase (EC 2.4.1.178) is an enzyme that catalyzes the chemical reaction

hydroxymandelonitrile glucosyltransferase
Identifiers
EC no.2.4.1.178
CAS no.89287-39-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
UDP-glucose + 4-hydroxymandelonitrile UDP + taxiphyllin

Thus, the two substrates of this enzyme are UDP-glucose and 4-hydroxymandelonitrile, whereas its two products are UDP and taxiphyllin.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:4-hydroxymandelonitrile glucosyltransferase. Other names in common use include cyanohydrin glucosyltransferase, and uridine diphosphoglucose-cyanohydrin glucosyltransferase. This enzyme participates in tyrosine metabolism.

References

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  • Hosel W, Schiel O (1984). "Biosynthesis of cyanogenic glucosides: in vitro analysis of the glucosylation step". Arch. Biochem. Biophys. 229 (1): 177–86. doi:10.1016/0003-9861(84)90142-5. PMID 6230992.
  • Poulton JE, Shin SI (1983). "Prunasin biosynthesis by cell-free-extracts from black cherry (Prunus serotina Ehrh) fruits and leaves". Z. Naturforsch. C: Biosci. 38: 369–374.