Wikipedia

Howard Lipshitz

Howard David Lipshitz (born October 30, 1955) is an American and Canadian biologist who does genetic research on the fruit fly, Drosophila.

Howard Lipshitz
Born (1955-10-30) October 30, 1955 (age 68)
South Africa
CitizenshipUnited States, Canada
EducationUniversity of Natal
Yale University
Scientific career
FieldsGenetics, Developmental Biology, Genomics
Institutions
Doctoral advisorDouglas Kankel
Other academic advisorsDavid Hogness

Early life and education edit

Lipshitz was born and raised in Durban, South Africa, where he attended the University of Natal (now the University of Kwazulu-Natal), obtaining a B.Sc. in Biological Sciences and Mathematical Statistics (1976) and a B.Sc.(Hons.) cum laude in Biological Sciences (1977). He completed his M. Phil. (1980) and Ph.D. (1983) degrees in Biology at Yale University with Douglas R. Kankel, working on Drosophila developmental neurogenetics. He then carried out postdoctoral research in the Biochemistry Department at Stanford University with David Hogness, where he defined the first long non-coding RNA, from the Bithorax complex of Drosophila.[1]

Career edit

In 1986 Lipshitz was appointed an Assistant Professor of Biology at the California Institute of Technology in Pasadena and promoted to Associate Professor in 1992. In 1995 he and his family moved to Toronto, where he held leadership positions at the Hospital for Sick Children's Research Institute (1996–2005) and at the University of Toronto, the latter as chair of its Department of Molecular Genetics (2005–2016). He served on the board of directors of the Society for Developmental Biology (2000–2006) and the Drosophila Board (2006–2009). He is one of the founders of the Rare Diseases Models and Mechanisms Network, Canada,[2] serving on its Scientific Advisory Committee since 2011. He was Associate Editor (2011–2016), then Senior Editor (2016–2020) of G3: Genes, Genomes, Genetics and in January 2021 was appointed Editor-in-Chief[3] of Genetics (journal). Both are peer-edited scientific journals published by the Genetics Society of America. He is a Fellow of the American Association for the Advancement of Science.

Research edit

Lipshitz studies embryonic development and post-transcriptional regulation of gene expression in Drosophila with a focus on mRNA translation, stability and localization during the Maternal to zygotic transition[4] and the role of RNA-binding proteins in this process.[5][6] With collaborators he developed a panel of phage-displayed synthetic antibodies that recognize RNA-binding proteins[7] and has used these to carry out-genome-wide studies of their mechanisms, functions and binding specificity (e.g.[8][9][10]). He also collaborates with scientists who study mammalian development, using Drosophila as a model in which to elucidate the molecular functions of evolutionarily conserved genes (e.g.[11][12][13]). Lipshitz has edited several books, most notably the collected works of his late colleague at Caltech, Nobel Laureate Edward B. Lewis, in which he provided detailed historical and scientific commentary on Lewis' contributions.[14]

Awards and honors edit

References edit

  1. ^ Lipshitz, H D; Peattie, D A; Hogness, D S (1 May 1987). "Novel transcripts from the Ultrabithorax domain of the bithorax complex". Genes & Development. 1 (3): 307–322. doi:10.1101/gad.1.3.307. PMID 3119423.
  2. ^ Boycott, Kym M.; Campeau, Philippe M.; Howley, Heather E.; Pavlidis, Paul; Rogic, Sanja; Oriel, Christine; Berman, Jason N.; Hamilton, Robert M.; Hicks, Geoffrey G.; Lipshitz, Howard D.; Masson, Jean-Yves; Shoubridge, Eric. A.; Junker, Anne; Leroux, Michel R.; McMaster, Christopher R.; Michaud, Jaques L.; Turvey, Stuart E.; Dyment, David; Innes, A. Micheil; van Karnebeek, Clara D.; Lehman, Anna; Cohn, Ronald D.; MacDonald, Ian M.; Rachubinski, Richard A.; Frosk, Patrick; Vandersteen, Anthony; Wozniak, Richard W.; Pena, Izabella A.; Wen, Xiao-Yan; Lacaze-Masmonteil, Thierry; Rankin, Catharine; Hieter, Philip (February 2020). "The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms". The American Journal of Human Genetics. 106 (2): 143–152. doi:10.1016/j.ajhg.2020.01.009. PMC 7010971. PMID 32032513.
  3. ^ "Genetics Society of America announces Howard Lipshitz as new Editor in Chief of GENETICS". Genes to Genomes. 30 September 2020.
  4. ^ Vastenhouw, Nadine L.; Cao, Wen Xi; Lipshitz, Howard D. (1 June 2019). "The maternal-to-zygotic transition revisited". Development. 146 (11): dev161471. doi:10.1242/dev.161471. PMID 31189646. S2CID 189816312.
  5. ^ Cao, Wen Xi; Kabelitz, Sarah; Gupta, Meera; Yeung, Eyan; Lin, Sichun; Rammelt, Christiane; Ihling, Christian; Pekovic, Filip; Low, Timothy C.H.; Siddiqui, Najeeb U.; Cheng, Matthew H.K.; Angers, Stephane; Smibert, Craig A.; Wühr, Martin; Wahle, Elmar; Lipshitz, Howard D. (June 2020). "Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition". Cell Reports. 31 (12): 107783. doi:10.1016/j.celrep.2020.107783. PMC 7372737. PMID 32579915.
  6. ^ Tadros, Wael; Goldman, Aaron L.; Babak, Tomas; Menzies, Fiona; Vardy, Leah; Orr-Weaver, Terry; Hughes, Timothy R.; Westwood, J. Timothy; Smibert, Craig A.; Lipshitz, Howard D. (January 2007). "SMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila and Its Translation Is Activated by the PAN GU Kinase". Developmental Cell. 12 (1): 143–155. doi:10.1016/j.devcel.2006.10.005. PMID 17199047.
  7. ^ Na, Hong; Laver, John D.; Jeon, Jouhyun; Singh, Fateh; Ancevicius, Kristin; Fan, Yujie; Cao, Wen Xi; Nie, Kun; Yang, Zhenglin; Luo, Hua; Wang, Miranda; Rissland, Olivia; Westwood, J. Timothy; Kim, Philip M.; Smibert, Craig A.; Lipshitz, Howard D.; Sidhu, Sachdev S. (April 2016). "A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes". RNA. 22 (4): 636–655. doi:10.1261/rna.055186.115. PMC 4793217. PMID 26847261.
  8. ^ Laver, John D.; Li, Xiao; Ancevicius, Kristin; Westwood, J. Timothy; Smibert, Craig A.; Morris, Quaid D.; Lipshitz, Howard D. (November 2013). "Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity". Nucleic Acids Research. 41 (20): 9438–9460. doi:10.1093/nar/gkt702. PMC 3814352. PMID 23945942.
  9. ^ Laver, John D; Li, Xiao; Ray, Debashish; Cook, Kate B; Hahn, Noah A; Nabeel-Shah, Syed; Kekis, Mariana; Luo, Hua; Marsolais, Alexander J; Fung, Karen YY; Hughes, Timothy R; Westwood, J Timothy; Sidhu, Sachdev S; Morris, Quaid; Lipshitz, Howard D; Smibert, Craig A (December 2015). "Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition". Genome Biology. 16 (1): 94. doi:10.1186/s13059-015-0659-4. PMC 4460960. PMID 25962635.
  10. ^ Laver, John D.; Ly, Jimmy; Winn, Allison K.; Karaiskakis, Angelo; Lin, Sichun; Nie, Kun; Benic, Giulia; Jaberi-Lashkari, Nima; Cao, Wen Xi; Khademi, Alireza; Westwood, J. Timothy; Sidhu, Sachdev S.; Morris, Quaid; Angers, Stephane; Smibert, Craig A.; Lipshitz, Howard D. (March 2020). "The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs". Cell Reports. 30 (10): 3353–3367.e7. doi:10.1016/j.celrep.2020.02.066. PMID 32160542.
  11. ^ Cohen, Brenda; Bashirullah, Arash; Dagnino, Lina; Campbell, Christine; Fisher, William W.; Leow, Ching Ching; Whiting, Elisabeth; Ryan, David; Zinyk, Dawn; Boulianne, Gabrielle; Hui, Chi-chung; Gallic, Brenda; Phillips, Robert A.; Lipshitz, Howard D.; Egan, Sean E. (July 1997). "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila". Nature Genetics. 16 (3): 283–288. doi:10.1038/ng0797-283. PMID 9207795. S2CID 28033622.
  12. ^ Sing, Angela; Pannell, Dylan; Karaiskakis, Angelo; Sturgeon, Kendra; Djabali, Malek; Ellis, James; Lipshitz, Howard D.; Cordes, Sabine P. (September 2009). "A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain". Cell. 138 (5): 885–897. doi:10.1016/j.cell.2009.08.020. PMID 19737517. S2CID 8103493.
  13. ^ Amadei, Gianluca; Zander, Mark A.; Yang, Guang; Dumelie, Jason G.; Vessey, John P.; Lipshitz, Howard D.; Smibert, Craig A.; Kaplan, David R.; Miller, Freda D. (25 November 2015). "A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis". The Journal of Neuroscience. 35 (47): 15666–15681. doi:10.1523/JNEUROSCI.2172-15.2015. PMC 6705466. PMID 26609159.
  14. ^ Lipshitz, Howard D., ed. (2007). Genes, Development and Cancer: The Life and Work of Edward B. Lewis (2 ed.). Dordrecht, Netherlands: Springer Netherlands. ISBN 978-1-4020-6343-5.
  15. ^ a b c "The Maternal-to-Zygotic Transition, Volume 113". The Maternal-to-Zygotic Transition, Volume 113. Elsevier.
  16. ^ "Profile - The Helen Hay Whitney Foundation". The Helen Hay Whitney Foundation.
  17. ^ "Howard D. Lipshitz - Searle Scholars Program". Searle Scholars Program.
  18. ^ "Elected Fellows". American Association for the Advancement of Science.
  19. ^ "Lipshitz Biography 202102" (PDF). University of Toronto.
  20. ^ "Honorary Staff - People - School of Biomedical Sciences, HKU". Honorary Staff - People - School of Biomedical Sciences, HKU. The University of Hong Kong.
  21. ^ "Lipshitz CV 20210623" (PDF). University of Toronto.
  22. ^ "Trustees, Administration, Faculty" (PDF). California Institute of Technology.
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