Heat-responsive protein 12

Ribonuclease UK114 is an enzyme that in humans is encoded by the HRSP12 gene.

RIDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ONI
Identifiers
Aliases	RIDA, P14.5, PSP, UK114, HRSP12, Heat-responsive protein 12, reactive intermediate imine deaminase A homolog, hp14.5
External IDs	OMIM: 602487 MGI: 1095401 HomoloGene: 4261 GeneCards: RIDA
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.2 Start 98,102,344 bp End 98,117,171 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.1 Start 34,484,167 bp End 34,495,401 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney kidney tubule caudate nucleus nucleus accumbens putamen amygdala glomerulus hypothalamus metanephric glomerulus Top expressed in kidney left lobe of liver proximal tubule yolk sac cerebellar cortex cerebellar vermis gallbladder globus pallidus anterior horn of spinal cord nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity ion binding long-chain fatty acid binding transition metal ion binding hydrolase activity RNA binding deaminase activity endoribonuclease activity, producing 3'-phosphomonoesters Cellular component cytosol mitochondrion extracellular exosome nucleus cytoplasm mitochondrial matrix peroxisome Biological process kidney development lung development G1 to G0 transition response to lipid brain development response to salt negative regulation of epithelial cell proliferation RNA phosphodiester bond hydrolysis, endonucleolytic organonitrogen compound catabolic process negative regulation of translation L-threonine catabolic process to glycine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10247 15473 Ensembl ENSG00000132541 ENSMUSG00000022323 UniProt P52758 P52760 RefSeq (mRNA) NM_005836 NM_008287 RefSeq (protein) NP_005827 NP_032313 Location (UCSC) Chr 8: 98.1 – 98.12 Mb Chr 15: 34.48 – 34.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Mistiniene E, Pozdniakovaite N, Popendikyte V, Naktinis V (2006). "Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF". Int. J. Biol. Macromol. 37 (1–2): 61–8. doi:10.1016/j.ijbiomac.2005.08.008. PMID 16198412.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Manjasetty BA, Delbrück H, Pham DT, et al. (2004). "Crystal structure of Homo sapiens protein hp14.5". Proteins. 54 (4): 797–800. doi:10.1002/prot.10619. PMID 14997576. S2CID 723244.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kanouchi H, Oka T, Asagi K, et al. (2000). "Expression and cellular distribution of perchloric acid-soluble protein is dependent on the cell-proliferating states of NRK-52E cells". Cell. Mol. Life Sci. 57 (7): 1103–8. doi:10.1007/PL00000746. PMID 10961346. S2CID 22844282.
• Morishita R, Kawagoshi A, Sawasaki T, et al. (1999). "Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis". J. Biol. Chem. 274 (29): 20688–92. doi:10.1074/jbc.274.29.20688. PMID 10400702.
• Colombo I, Ceciliani F, Ronchi S, et al. (1998). "cDNA cloning and Escherichia coli expression of UK114 tumor antigen". Biochim. Biophys. Acta. 1442 (1): 49–59. doi:10.1016/s0167-4781(98)00120-1. PMID 9767104.
• Racca S, Di Carlo F, Bartorelli A, et al. (1998). "Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114". Virchows Arch. 431 (5): 323–8. doi:10.1007/s004280050106. PMID 9463573. S2CID 30926226.
• Oka T, Tsuji H, Noda C, et al. (1996). "Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis". J. Biol. Chem. 270 (50): 30060–7. doi:10.1074/jbc.270.50.30060. PMID 8530410.

External links

• HRSP12 human gene location in the UCSC Genome Browser.
• HRSP12 human gene details in the UCSC Genome Browser.