Inhibitors
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In 2023 the first potent and selective HSD17B13 inhibitor, BI-3231, was reported.[8] The inhibitor meets the quality criteria of a 'Donated Chemical Probe' as defined by the Structural Genomics Consortium .[9]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000170509 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034528 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Zhu YS, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition" . In Lightman S (ed.). Hormones, Brain and Behavior . Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2 .
^ Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery . John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9 .
^ Su W, Wang Y, Jia X, Wu W, Li L, Tian X, Li S, Wang C, Xu H, Cao J, Han Q, Xu S, Chen Y, Zhong Y, Zhang X, Liu P, Gustafsson JÅ, Guan Y (2014). "Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease" . Proceedings of the National Academy of Sciences of the United States of America . 111 (31): 11437–42. Bibcode :2014PNAS..11111437S . doi :10.1073/pnas.1410741111 . PMC 4128098 . PMID 25028495 .
^ Thamm, Sven; Willwacher, Marina K.; Aspnes, Gary E.; et al. (2023). "Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science" . Journal of Medicinal Chemistry . 66 (4): 2832–2850. doi :10.1021/acs.jmedchem.2c01884 . PMC 9969402 . PMID 36727857 .
^ "Donated Chemical Probes" . thesgc.org . Retrieved July 31, 2023 .