Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.[5][6][7]

HNRNPUL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPUL1, E1B-AP5, E1BAP5, HNRPUL1, heterogeneous nuclear ribonucleoprotein U like 1
External IDsOMIM: 605800; MGI: 2443517; HomoloGene: 31419; GeneCards: HNRNPUL1; OMA:HNRNPUL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144922
NM_178089
NM_001360789

RefSeq (protein)

NP_001287945
NP_001308137
NP_001308140
NP_008971
NP_653333

NP_659171
NP_835190
NP_001347718

Location (UCSC)Chr 19: 41.26 – 41.31 MbChr 7: 25.42 – 25.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.[7]

Interactions

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HNRPUL1 has been shown to interact with BRD7[6] and PRMT2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105323Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040725Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T (Oct 1998). "E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs". J Virol. 72 (10): 7960–71. doi:10.1128/JVI.72.10.7960-7971.1998. PMC 110131. PMID 9733834.
  6. ^ a b Kzhyshkowska J, Rusch A, Wolf H, Dobner T (Apr 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277. PMID 12489984.
  7. ^ a b "Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1".
  8. ^ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.

Further reading

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