Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.[5][6]

HNRNPA0
Identifiers
AliasesHNRNPA0, HNRPA0, heterogeneous nuclear ribonucleoprotein A0
External IDsOMIM: 609409; MGI: 1924384; HomoloGene: 136809; GeneCards: HNRNPA0; OMA:HNRNPA0 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006805

NM_029872

RefSeq (protein)

NP_006796

NP_084148

Location (UCSC)Chr 5: 137.75 – 137.75 MbChr 13: 58.27 – 58.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177733Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007836Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Myer VE, Steitz JA (Dec 1995). "Isolation and characterization of a novel, low abundance hnRNP protein: A0". RNA. 1 (2): 171–82. PMC 1369071. PMID 7585247.
  6. ^ a b "Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0".

Further reading

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