HLA-DQ3


major histocompatibility complex, class II, DQ3
Haplotypes	DQA10303:DQB10301 DQA10401:DQB10301 DQA10505:DQB10301 DQA10601:DQB10301 DQA103:DQB10302 DQA10301:DQB10303
Structure (See HLA-DQ)
Identifiers	alpha 1 0301 0302 0303 0401 0505 0601
Symbol(s)	HLA-DQA1^{[permanent dead link]}
EBI-HLA	DQA1*0301
EBI-HLA	DQA1*0302
EBI-HLA	DQA1*0303
EBI-HLA	DQA1*0401
EBI-HLA	DQA1*0505
Identifiers	beta 1 0301 0302 *0303
Symbol(s)	HLA-DQB1
EBI-HLA	DQB1*0301
EBI-HLA	DQB1*0302
EBI-HLA	DQB1*0303
Shared data
Locus	chr.6 6p21.31

Within molecular and cell biology, HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3^[1] a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2.^[2] While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. For this reason they are best treated independently.

Serology

DQ3, DQ7, DQ8, and DQ9 recognition of Some DRB1*and ^[3]
DQB1*	DQ7	DQ3	DQ8	Sample
allele	%	%	%	size (N)
0301	85	40	1	12220
0304	40	35	8	111
				.
	DQ8	DQ3	DQ7	N
0302	66	25	1	6657
0305	34	30		70
	DQ9	DQ3	DQ2	N
0303	67	12	11
		DQ7	DQ8	N
0303		1	1	2563

The serotyping efficiency of DQ3 recognition relative to DQ2, DQ7, DQ8, and DQ9 is shown to the left. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ3 recognition is relatively low and error prone. This compares to genotyping efficiency of 100%. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DBB1*group recognizes DQB1*0303 as efficiently as DQ3.

For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study. Nonetheless, it is still widely used and association purported in the literature.

Alleles

DQB1*0301

DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7

DQB1*0302

DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8

DQB1*0303

DQB1*0303 the DQ9 gene, is detailed on HLA-DQ9

DQB1*0304

DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7

DQB1*0305

DQB1*0305 is similar in structure and function to DQB1*0302 generally considered to be HLA-DQ8

References

^ Goyert SM, Silver J (1983). "Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 80 (18): 5719–23. Bibcode:1983PNAS...80.5719G. doi:10.1073/pnas.80.18.5719. PMC 384330. PMID 6193521.
^ Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. S2CID 20971131.
^ derived from IMGT/HLA

[pmid6193521-1] Goyert SM, Silver J (1983). "Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 80 (18): 5719–23. Bibcode:1983PNAS...80.5719G. doi:10.1073/pnas.80.18.5719. PMC 384330. PMID 6193521.

[pmid2412948-2] Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. S2CID 20971131.

[3] rived from IMGT/HLA

[1]

[2]

[3]