major histocompatibility complex (human), class I, B73
Alleles B*7301
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*7301
Locus chr.6 6p21.31

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product.[1] Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes.[2] B73 is more common in Western Indian Ocean, Mediterranean and Africa. (For terminology help see: HLA-serotype tutorial)

Serotype

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B*73:01 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*55:03.[3]

B73 serotype recognition of B*7301 allele-group gene products[4]
B*73 B73 Other Sample
allele % % size (N)
7301 22 69 106

B*7301 frequencies

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HLA B*7301 frequencies
freq
ref. Population (%)
[5] Parsi (Karachi, Pakistan) 4.9
[5] United Arab Emirates 2.0
[5] Italy 2.0
[5] Seri (Sonora, Mexico) 1.5
[5] Purépecha (Michoacán, Mexico) 1.5
[5] Jews (Israel) (*2 studies) 1.2
[5] Beti (Cameroon) 1.1
[5] Casablanca (Morocco) 0.9
[5] Tbilisi (Georgia) 0.9
[5] Mossi (Burkina Faso) 0.9
[5] Bulgaria 0.9
[5] Sudanese 0.8
[5] Tuva (Russia) (2) 0.8
[5] Oman 0.8
[5] Bamileke (Cameroon) 0.6
[5] Pathan (Pakistan) 0.5
[5] Khalkha (Mongolia) 0.5
[5] Druse Arabs (Israel) 0.5
[5] Baloch (Iran) 0.5
[5] Manchester (England) 0.5
[5] Algeria (1) 0.5
[5] Turkey 0.4
[5] Amman (Jordan) 0.3
[5] Shona (Harare, Zimbabwe) 0.2
[5] Republic of Macedonia 0.2
[5] Nandi (Kenya) 0.2
[5] Luo (Kenya) 0.2
[5] Campania (Italy) 0.2
[5] Greece 0.2

References

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  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU (1995). "Antigenic characteristics and cDNA sequences of HLA-B73". Eur. J. Immunogenet. 22 (3): 231–40. doi:10.1111/j.1744-313X.1995.tb00237.x. PMID 8547229.
  3. ^ Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  4. ^ derived from IMGT/HLA
  5. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.