major histocompatibility complex (human), class I, B42
Alleles B*4201
B*4202
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*4201
EBI-HLA B*4202
Locus chr.6 6p21.31

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products.[1] HLA-B*4201 is common in Central Africa. (For terminology help see: HLA-serotype tutorial)

Serotype

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B42 serotype recognition of Some HLA B*42 allele-group gene products[2]
B*42 B42 other Sample
allele % % size (N)
4201 93 2 1015
4202 95 80

Serological typing for B*4201 and B*4202 is relatively efficient.

B*4201 allele frequencies

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HLA B*4201 frequencies
freq
ref. Population (%)
[3] Zambia Lusaka 14.8
[3] Mali Bandiagara 13.8
[3] Burkina Faso Mossi 13.2
[3] South African Natal Zulu 12.0
[3] Burkina Faso Rimaibe 9.6
[3] South Africa Tswana 8.5
[3] Kenya Luo 7.7
[3] Kenya 7.3
[3] Kenya Nandi 6.9
[3] Zimbabwe Harare Shona 6.9
[3] Saudi Arabia 5.6
[3] Cameroon Yaounde 4.9
[3] Cameroon Beti 4.0
[3] Cameroon Bamileke 3.9
[3] Cameroon Sawa 3.8
[3] Ivory Coast Akan Adiopodoume 3.4
[3] Israel Gaza Palestinians 2.4
[3] India North Delhi 2.2
[3] Senegal Niokholo Mandenka 1.6
[3] Mbenzele Pygmy (C. Afr. Rep.) 1.5
[3] Iran Baloch 1.5
[3] Pakistan Baloch 1.5
[3] Sudanese 1.5
[3] Tunisia 1.5
[3] Pakistan Brahui 1.4
[3] Cameroon Bamileke 1.3
[3] Oman 1.3
[3] Sudanese 1.3
[3] Tunisia Tunis 1.1
[3] Zimbabwe Harare Shona 1.1
[3] Cameroon Bakola Pygmy 1.0
[3] Pakistan Pathan 1.0
[3] Portugal Centre 1.0
[3] Saudi Arabia Guraiat and Hail 1.0
[3] Morocco Casablanca 0.9
[3] Senegal Dakar 0.9
[3] Uganda Kampala 0.9
[3] Cape Verde Southeastern Islands 0.8
[3] Guinea Bissau 0.8
[3] United Arab Emerates 0.8
[3] Morocco Nador Metalsa Class I 0.7
[3] Pakistan Karachi Parsi 0.6
[3] Spain Majorca 0.6
[3] China Yunnan Han pop2 0.5
[3] England Newcastle 0.5
[3] Israel Arab Druse 0.5
[3] Israel Jews 0.5
[3] Italy Rome 0.5
[3] Guadalajara Mestizos (2) (Mexico) 0.5
[3] Morocco 0.5
[3] Pakistan Sindhi 0.5
[3] Senegal Niokholo Mandenka 0.5
[3] Singapore Riau Malay 0.5

References

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  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.