HES3

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.

HES3
Identifiers
Aliases	HES3, bHLHb43, hes family bHLH transcription factor 3
External IDs	OMIM: 609971; MGI: 104877; HomoloGene: 7358; GeneCards: HES3; OMA:HES3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.31 Start 6,244,179 bp End 6,245,578 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 83.01 cM Start 152,370,429 bp End 152,376,119 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa Top expressed in urethra male urethra female urethra cerebellar cortex embryo hair tail of embryo Purkinje cell adrenal medulla pars intermedia More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding transcription factor binding protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleus Biological process hindbrain morphogenesis trochlear nerve development midbrain-hindbrain boundary morphogenesis negative regulation of transcription, DNA-templated in utero embryonic development negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated regulation of timing of neuron differentiation regulation of neurogenesis oculomotor nerve development transcription, DNA-templated midbrain development positive regulation of transcription by RNA polymerase II neural tube development somitogenesis Notch signaling pathway cell differentiation anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390992 15207 Ensembl ENSG00000173673 ENSMUSG00000028946 UniProt Q5TGS1 Q61657 RefSeq (mRNA) NM_001024598 NM_008237 RefSeq (protein) NP_001019769 NP_032263 NP_001390720 NP_001390721 NP_001390722 NP_001390723 Location (UCSC) Chr 1: 6.24 – 6.25 Mb Chr 4: 152.37 – 152.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
• Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (February 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
• Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. Bibcode:2013NatSR...3E1095P. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.