Guanylate cyclase activator 2B

Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene. [5]

GUCA2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGUCA2B, GCAP-II, UGN, guanylate cyclase activator 2B
External IDsOMIM: 601271; MGI: 1270851; HomoloGene: 5150; GeneCards: GUCA2B; OMA:GUCA2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007102

NM_008191

RefSeq (protein)

NP_009033

NP_032217

Location (UCSC)Chr 1: 42.15 – 42.16 MbChr 4: 119.51 – 119.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000044012Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032978Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Guanylate cyclase activator 2B". Retrieved 2017-07-04.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.