Grigorenko (Russian: Григоренко) is a surname of Ukrainian origin. It means "son of Grigoriy (Gregory)" and may refer to the following notable people:
- Pyotr Grigorenko, Soviet general and dissident communist
- Igor Grigorenko, Russian professional ice hockey right winger
- Mikhail Grigorenko, Russian junior ice hockey centre
- Julia Grigorenko, Ukrainian ice dancer
- Paulina Grigorenko, Russian 1992 Amsterdam Marathon female winner