Wikipedia

Gerard Evan

Gerard Ian Evan FRS, FMedSci (born 17 August 1955) is a British biologist and, since May 2022, Professor of Cancer Biology at King's College London and a principal group leader in the Francis Crick Institute. Prior to this he was Sir William Dunn Professor and Head of Biochemistry at the University of Cambridge (2009-2022).[11][13]

Gerard Evan
Born (1955-08-17) 17 August 1955 (age 68)[10]
Alma materSt Peter's College, Oxford
King's College, Cambridge[10]
Known forDisease Models & Mechanisms
AwardsFellow of the Royal Society (2004)
FMedSci (1999)[1]
PhD (1982)
Scientific career
FieldsCancer[2][3][4][5][6][7]
Disease biology
Myc regulator gene[8]
p53 tumour suppressor[9]
InstitutionsUniversity of Oxford
University of Cambridge
UCSF[10][11]
Cancer Research UK[12]
Ensemble Therapeutics
ThesisMonoclonal antibodies as reagents for the analysis of cell surfaces (1982)
Websitewww.bioc.cam.ac.uk/uto/evan
labmed.ucsf.edu/about/faculty/pathology-gevan.html

Education edit

Evan was educated at St Peter's College, Oxford, where he studied Biochemistry, and King's College, Cambridge, where he was awarded his PhD in 1982 for research using Monoclonal antibodies.[10][14]

Research edit

Evan does research to the determine the molecular basis of cancer.[15][16][17][18][19][20][21][22]

Career edit

Prior to Cambridge, Evan was Royal Society Napier Professor at University College London and the Imperial Cancer Research Fund (1988-99), then Gerson & Barbara Bass Bakar Distinguished Professor of Cancer Biology, at University of California, San Francisco (1999-2011).

References edit

  1. ^ http://www.acmedsci.ac.uk/p59fid5303.html [dead link]
  2. ^ Finch, A. J.; Soucek, L.; Junttila, M. R.; Swigart, L. B.; Evan, G. I. (2009). "Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/ -Catenin Pathway Activation". Molecular and Cellular Biology. 29 (19): 5306–5315. doi:10.1128/MCB.01745-08. PMC 2747972. PMID 19635809.
  3. ^ Garcia, D.; Warr, M. R.; Martins, C. P.; Brown Swigart, L.; Passegue, E.; Evan, G. I. (2011). "Validation of MdmX as a therapeutic target for reactivating p53 in tumors". Genes & Development. 25 (16): 1746–1757. doi:10.1101/gad.16722111. PMC 3165938. PMID 21852537.
  4. ^ Murphy, D. J.; Junttila, M. R.; Pouyet, L.; Karnezis, A.; Shchors, K.; Bui, D. A.; Brown-Swigart, L.; Johnson, L.; Evan, G. I. (2008). "Distinct Thresholds Govern Myc's Biological Output in Vivo". Cancer Cell. 14 (6): 447–457. doi:10.1016/j.ccr.2008.10.018. PMC 2723751. PMID 19061836.
  5. ^ Sodir, N. M.; Swigart, L. B.; Karnezis, A. N.; Hanahan, D.; Evan, G. I.; Soucek, L. (2011). "Endogenous Myc maintains the tumor microenvironment". Genes & Development. 25 (9): 907–916. doi:10.1101/gad.2038411. PMC 3084025. PMID 21478273.
  6. ^ Kain, K. (2008). "The future of cancer therapy: An interview with Gerard Evan". Disease Models and Mechanisms. 1 (2–3): 90–93. doi:10.1242/dmm.001396. PMC 2562192. PMID 19048069.
  7. ^ Anon (2008). "Making the paper: Gerard Evan". Nature. 455 (7213): xiii. doi:10.1038/7213xiiia. S2CID 4410691.
  8. ^ Evan, G. (2012). "Taking a Back Door to Target Myc". Science. 335 (6066): 293–294. Bibcode:2012Sci...335..293E. doi:10.1126/science.1217819. PMID 22267799. S2CID 26445434.
  9. ^ Junttila, Melissa R.; Evan, Gerard I. (2009). "P53 — a Jack of all trades but master of none". Nature Reviews Cancer. 9 (11): 821–829. doi:10.1038/nrc2728. PMID 19776747. S2CID 29250930.
  10. ^ a b c d "EVAN, Prof. Gerard Ian". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
  11. ^ a b "UCSF Departments of Pathology and Laboratory Medicine | About | Faculty | Gerard I. Evan, PhD, FRS, FMedSci". Archived from the original on 1 June 2013.
  12. ^ "Gerard Evan : Cancer Research UK". Archived from the original on 10 March 2014.
  13. ^ Gerard Evan publications indexed by Microsoft Academic
  14. ^ Evan, Gerard (1982). Monoclonal antibodies as reagents for the analysis of cell surfaces (PhD thesis). University of Cambridge.
  15. ^ Christophorou, M. A.; Ringshausen, I.; Finch, A. J.; Swigart, L. B.; Evan, G. I. (2006). "The pathological response to DNA damage does not contribute to p53-mediated tumour suppression". Nature. 443 (7108): 214–217. Bibcode:2006Natur.443..214C. doi:10.1038/nature05077. PMID 16957739. S2CID 4417336.
  16. ^ Junttila, M. R.; Karnezis, A. N.; Garcia, D.; Madriles, F.; Kortlever, R. M.; Rostker, F.; Brown Swigart, L.; Pham, D. M.; Seo, Y.; Evan, G. I.; Martins, C. P. (2010). "Selective activation of p53-mediated tumour suppression in high-grade tumours". Nature. 468 (7323): 567–571. Bibcode:2010Natur.468..567J. doi:10.1038/nature09526. PMC 3011233. PMID 21107427.
  17. ^ Soucek, L.; Whitfield, J.; Martins, C. P.; Finch, A. J.; Murphy, D. J.; Sodir, N. M.; Karnezis, A. N.; Swigart, L. B.; Nasi, S.; Evan, G. I. (2008). "Modelling Myc inhibition as a cancer therapy". Nature. 455 (7213): 679–683. Bibcode:2008Natur.455..679S. doi:10.1038/nature07260. PMC 4485609. PMID 18716624.
  18. ^ Evan, Gerard I.; Vousden, Karen H. (2001). "Proliferation, cell cycle and apoptosis in cancer". Nature. 411 (6835): 342–348. Bibcode:2001Natur.411..342E. doi:10.1038/35077213. PMID 11357141. S2CID 4414024.
  19. ^ Hueber, A. O.; Zörnig, M.; Lyon, D.; Suda, T.; Nagata, S.; Evan, G. I. (1997). "Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis". Science. 278 (5341): 1305–1309. Bibcode:1997Sci...278.1305H. doi:10.1126/science.278.5341.1305. PMID 9360929.
  20. ^ Chittenden, T.; Harrington, E. A.; O'Connor, R.; Remington, C.; Lutz, R. J.; Evan, G. I.; Guild, B. C. (1995). "Induction of apoptosis by the Bcl-2 homologue Bak". Nature. 374 (6524): 733–736. Bibcode:1995Natur.374..733C. doi:10.1038/374733a0. PMID 7715730. S2CID 4315947.
  21. ^ Fanidi, A.; Harrington, E. A.; Evan, G. I. (1992). "Cooperative interaction between c-myc and bcl-2 proto-oncogenes". Nature. 359 (6395): 554–556. Bibcode:1992Natur.359..554F. doi:10.1038/359554a0. PMID 1406976. S2CID 4247014.
  22. ^ Amati, B.; Dalton, S.; Brooks, M. W.; Littlewood, T. D.; Evan, G. I.; Land, H. (1992). "Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max". Nature. 359 (6394): 423–426. Bibcode:1992Natur.359..423A. doi:10.1038/359423a0. PMID 1406955. S2CID 4362486.

External links edit

Academic offices
Preceded by
[[]]
 Professor of Cancer Biology at the King's College London
2020–present 		Incumbent
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