Gene Tools, LLC is a limited liability company located in Philomath, Oregon, United States that manufactures Morpholino antisense oligos and delivery reagents.[1][2] Gene Tools was founded in 1997 and began regularly shipping custom-sequence Morpholino oligos in 2000. Current products include Morpholino oligos and Vivo-Morpholinos (for improved delivery into cells).
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The manager and general partner, Jim Summerton, is a pioneer in antisense research,[3] conceived of and was co-inventor of the Morpholino antisense oligo structural type[4] and founded the first antisense therapeutics company, Sarepta Therapeutics Inc. (formerly AntiVirals Inc., renamed AVI BioPharma Inc., renamed Sarepta Therapeutics Inc.).
References edit
- ^ Summerton, JE (2005). "Endo-porter: a novel reagent for safe, effective delivery of substances into cells". Ann N Y Acad Sci. 1058 (1): 62–75. Bibcode:2005NYASA1058...62S. doi:10.1196/annals.1359.012. PMID 16394126. S2CID 28590429.
- ^ Morcos, PA (2001). "Achieving efficient delivery of morpholino oligos in cultured cells". Genesis. 30 (3): 94–102. doi:10.1002/gene.1039. PMID 11477682.
- ^ Summerton, JE (May 1979). "Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment of viral diseases and virally-mediated cancers". J. Theor. Biol. 78 (1): 77–99. Bibcode:1979JThBi..78...77S. doi:10.1016/0022-5193(79)90327-8. PMID 114718.
- ^ Summerton, J; Weller D (1997). "Morpholino Antisense Oligomers: Design, Preparation and Properties" (PDF). Antisense & Nucleic Acid Drug Development. 7 (3): 187–95. doi:10.1089/oli.1.1997.7.187. PMID 9212909. S2CID 19372403. Archived from the original (PDF) on 2019-02-19.
External links edit
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