Gamma-glutamyltransferase 1

Gamma-glutamyltransferase 1 (GGT1), also known as CD224 (Cluster of Differentiation 224), is a human gene.[5]

GGT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGT1, CD224, D22S672, D22S732, GGT, GGT 1, GTG, gamma-glutamyltransferase 1, GGTD
External IDsOMIM: 612346; MGI: 95706; HomoloGene: 68450; GeneCards: GGT1; OMA:GGT1 - orthologs
EC number3.4.19.13
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008116
NM_001305992

RefSeq (protein)

NP_001275762
NP_038265
NP_038347

Location (UCSC)Chr 22: 24.59 – 24.63 MbChr 10: 75.56 – 75.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100031Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006345Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GGT1 gamma-glutamyltransferase 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.