Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

GZMB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDsOMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004131
NM_001346011

NM_013542

RefSeq (protein)

NP_001332940
NP_004122

NP_038570

Location (UCSC)Chr 14: 24.63 – 24.63 MbChr 14: 56.5 – 56.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100453Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015437Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
  6. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: S01.010