Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.[5][6] Alternative names:[7]

GUCA1B
Identifiers
AliasesGUCA1B, GCAP2, GUCA2, RP48, guanylate cyclase activator 1B, GCAP 2
External IDsOMIM: 602275; MGI: 1194489; HomoloGene: 1586; GeneCards: GUCA1B; OMA:GUCA1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002098

NM_146079

RefSeq (protein)

NP_002089

NP_666191

Location (UCSC)Chr 6: 42.18 – 42.19 MbChr 17: 47.7 – 47.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Biological Role

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Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation.[8] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase.[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112599Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023979Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, et al. (February 1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi:10.1006/geno.1996.4513. PMID 9119368.
  6. ^ "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".
  7. ^ "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.
  8. ^ a b Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K (April 1994). "Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 4014–8. Bibcode:1994PNAS...91.4014G. doi:10.1073/pnas.91.9.4014. PMC 43713. PMID 7909609.

Further reading

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