GSPT2

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.

GSPT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KUJ
Identifiers
Aliases	GSPT2, ERF3B, GST2, G1 to S phase transition 2
External IDs	OMIM: 300418; MGI: 1316727; HomoloGene: 99786; GeneCards: GSPT2; OMA:GSPT2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.22 Start 51,743,442 bp End 51,746,232 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X C3 Start 93,679,675 bp End 93,686,850 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm germinal epithelium Epithelium of choroid plexus ventricular zone gonad ganglionic eminence Brodmann area 23 middle temporal gyrus retinal pigment epithelium hair follicle Top expressed in seminal vesicula primary oocyte zygote secondary oocyte dorsomedial hypothalamic nucleus suprachiasmatic nucleus efferent ductule ventromedial nucleus subiculum lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding translation release factor activity protein binding GTPase activity RNA binding Cellular component cytoplasm cytosol translation release factor complex Biological process translational termination cell cycle nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23708 14853 Ensembl ENSG00000189369 ENSMUSG00000071723 UniProt Q8IYD1 Q149F3 RefSeq (mRNA) NM_018094 NM_008179 RefSeq (protein) NP_060564 NP_032205 Location (UCSC) Chr X: 51.74 – 51.75 Mb Chr X: 93.68 – 93.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM]

Interactions

GSPT2 has been shown to interact with PABPC1.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Chauvin C, Salhi S, Le Goff C, et al. (2005). "Involvement of Human Release Factors eRF3a and eRF3b in Translation Termination and Regulation of the Termination Complex Formation". Mol. Cell. Biol. 25 (14): 5801–11. doi:10.1128/MCB.25.14.5801-5811.2005. PMC 1168810. PMID 15987998.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Le Goff C, Zemlyanko O, Moskalenko S, et al. (2003). "Mouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo". Genes Cells. 7 (10): 1043–57. doi:10.1046/j.1365-2443.2002.00585.x. PMID 12354098.
• Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.
• Hoshino S, Imai M, Mizutani M, et al. (1998). "Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1". J. Biol. Chem. 273 (35): 22254–9. doi:10.1074/jbc.273.35.22254. PMID 9712840.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IYD1 (Human Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)) at the PDBe-KB.