Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene.[5][6]

GRIN2C
Identifiers
AliasesGRIN2C, GluN2C, NMDAR2C, NR2C, glutamate ionotropic receptor NMDA type subunit 2C
External IDsOMIM: 138254; MGI: 95822; HomoloGene: 647; GeneCards: GRIN2C; OMA:GRIN2C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000835
NM_001278553

NM_010350

RefSeq (protein)

NP_000826
NP_001265482

NP_034480

Location (UCSC)Chr 17: 74.84 – 74.86 MbChr 11: 115.14 – 115.16 Mb
PubMed search[3][4]
Wikidata
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Function

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N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).[6]

Interactions

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GRIN2C has been shown to interact with DLG4[7] and DLG3.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161509Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020734Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.
  6. ^ a b "Entrez Gene: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C".
  7. ^ a b Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.