GRAM domain-containing 2B

GRAMD2B
Identifiers
Aliases	GRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDs	MGI: 1914815; HomoloGene: 32570; GeneCards: GRAMD2B; OMA:GRAMD2B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	126,496,494 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	56,636,864 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; corpus callosum; ; external globus pallidus; ; bronchial epithelial cell; ; jejunal mucosa; ; caudate nucleus; ; superior vestibular nucleus; ; amygdala; ; subthalamic nucleus;
	Top expressed in
	mucous cell of stomach; ; jejunum; ; islet of Langerhans; ; pyloric antrum; ; duodenum; ; epithelium of stomach; ; parotid gland; ; external carotid artery; ; internal carotid artery; ; left lobe of liver;
	More reference expression data
	n/a
Orthologs
	65983
	107022
	ENSG00000155324
	ENSMUSG00000001700
	Q96HH9
	Q6PEM6
NM_001146319; NM_001146320; NM_001146321; NM_001146322; NM_023927;
	NM_001349541; NM_001349542; NM_001349543; NM_001349544
	NM_026240; NM_001360917
NP_001139791; NP_001139792; NP_001139793; NP_001139794; NP_076416;
	NP_001336470; NP_001336471; NP_001336472; NP_001336473
	NP_080516; NP_001347846
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.^[5]^[6]

GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.^[7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.^[8]^[7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
^ "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
^ ^a ^b Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.

[6] "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.

[pmid29469807-7] Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.

[8] "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.

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