GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]

GRAMD4
Identifiers
AliasesGRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDsOMIM: 613691; MGI: 2676308; HomoloGene: 18199; GeneCards: GRAMD4; OMA:GRAMD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015124
NM_001366660

NM_001205353
NM_172611
NM_001379572

RefSeq (protein)

NP_055939
NP_001353589

NP_001192282
NP_766199
NP_001366501

Location (UCSC)Chr 22: 46.58 – 46.68 MbChr 15: 85.94 – 86.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075240Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035900Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
  6. ^ "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
  7. ^ Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177. S2CID 24578301.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.