Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene.[5][6]

GFPT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGFPT1, CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPT, GFPT1L, MSLG, CMS12, glutamine--fructose-6-phosphate transaminase 1
External IDsOMIM: 138292; MGI: 95698; HomoloGene: 68220; GeneCards: GFPT1; OMA:GFPT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002056
NM_001244710

NM_013528

RefSeq (protein)

NP_001231639
NP_002047

NP_038556

Location (UCSC)Chr 2: 69.32 – 69.39 MbChr 6: 87.02 – 87.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198380Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029992Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase". J Biol Chem. 267 (35): 25208–12. doi:10.1016/S0021-9258(19)74026-5. PMID 1460020.
  6. ^ a b "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1".

Further reading

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