Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.[3]

GCAT
Identifiers
AliasesGCAT, KBL, glycine C-acetyltransferase
External IDsOMIM: 607422; MGI: 1349389; HomoloGene: 8475; GeneCards: GCAT; OMA:GCAT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001171690
NM_014291

NM_001161712
NM_013847

RefSeq (protein)

NP_001165161
NP_055106

NP_001155184
NP_038875

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

References

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  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Glycine C-acetyltransferase".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.