GABRR2

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.

GABRR2
Identifiers
Aliases	GABRR2, gamma-aminobutyric acid type A receptor rho2 subunit, gamma-aminobutyric acid type A receptor subunit rho2
External IDs	OMIM: 137162; MGI: 95626; HomoloGene: 20471; GeneCards: GABRR2; OMA:GABRR2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q15 Start 89,254,464 bp End 89,315,299 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 A5|4 14.64 cM Start 33,062,999 bp End 33,095,865 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava gonad germ cell male germ cell skeletal muscle tissue deltoid muscle sperm tibialis anterior muscle spleen smooth muscle tissue Top expressed in neural layer of retina embryo embryo muscle of thigh blood right kidney superior colliculus epithelium of lens cerebellar cortex medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity protein domain specific binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport signal transduction visual perception chemical synaptic transmission ion transmembrane transport regulation of membrane potential nervous system process regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2570 14409 Ensembl ENSG00000111886 ENSMUSG00000023267 UniProt P28476 P56476 RefSeq (mRNA) NM_002043 NM_008076 RefSeq (protein) NP_002034 NP_032102 Location (UCSC) Chr 6: 89.25 – 89.32 Mb Chr 4: 33.06 – 33.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.

See also

• GABA_A-ρ receptor

Further reading

• Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. doi:10.1074/jbc.272.21.13750. PMID 9153229.
• Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716. S2CID 12933301.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. doi:10.1523/jneurosci.20-23-08643.2000. PMC 6773065. PMID 11102469.
• Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859. S2CID 54402119.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gamel-Didelon K, Kunz L, Fohr KJ, et al. (2003). "Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells". J. Biol. Chem. 278 (22): 20192–20195. doi:10.1074/jbc.M301729200. PMID 12660236.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• GABRR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.